Friday, June 10, 2022

3D Printed Tissuex

  Rice University graduate student Sean Bittner holds a 3D-printed scaffold created to help heal osteochondral injuries. Credit: Jeff Fitlow/Rice University

The scientists at Rice University and the University of Maryland engineered scaffolds that replicate the physical characteristics of osteochondral tissue -- hard bone beneath a compressible layer of cartilage that appears as the smooth surface on the ends of long bones.

Injuries to these bones, from small cracks to pieces that break off, can be painful and often stop athletes' careers in their tracks. Osteochondral injuries can also lead to disabling arthritis.

The gradient nature of cartilage-into-bone and its porosity have made it difficult to reproduce in the lab, but scientists have used 3D printing to fabricate what they believe will eventually be a suitable material for implantation.

"Athletes are disproportionately affected by these injuries, but they can affect everybody," said Sean Bittner, a third-year bioengineering graduate student at Rice, a National Science Foundation fellow. "I think this will be a powerful tool to help people with common sports injuries."

The key is mimicking tissue that turns gradually from cartilage (chondral tissue) at the surface to bone (osteo) underneath. The researchers led by bioengineer Antonios Mikos 3D printed a scaffold with custom mixtures of a polymer for the former and a ceramic for the latter with imbedded pores that would allow the patient's own cells and blood vessels to infiltrate the implant, eventually allowing it to become part of the natural bone and cartilage.

"For the most part, the composition will be the same from patient to patient," Bittner said. "There's porosity included so vasculature can grow in from the native bone. We don't have to fabricate the blood vessels ourselves."

In the future, the project will involve figuring out how to print an osteochondral implant that perfectly fits the patient and allows the porous implant to grow into and knit with the bone and cartilage.

Their results are reported in Acta Biomaterialia.


Friday, May 20, 2022

Should You File a Complaint?

 You may request a Statement of Complaint form by calling 1-800-822-2113 or 717-783-4849.

Saturday, May 7, 2022

Cornell Study on Psychopaths


Using computerized text analysis, Cornell professor of communication Jeff Hancock and colleagues at the University of British Columbia found that psychopathic criminals tend to make identifiable word choices when talking about their crimes. Hancock and UBC professor of psychology Michael Woodworth discussed the implications of their study at the October 17, 2011 Inside Cornell session at Cornell's ILR Conference Center in Midtown Manhattan.

Friday, February 4, 2022

Trust Matters

Medical malpractice injuries go beyond the body – they severely damage the trust between a patient and their medical professional. Patients depend upon the expertise and professional judgment from doctors, nurses, and other medical professionals, and when these professionals violate their role by deviating from the accepted standard of practice and causing harm to the patient, the damage caused can be extremely traumatic & change the entire course of your life.  A harmful deviation from the standard of care by a health care practitioner could lead to a medical malpractice lawsuit in Pennsylvania 

Sunday, January 2, 2022

Custom Implants


Case Reports

3D Printed Acetabular Components for Complex Revision Arthroplasty

Angela Yao et al. Indian J Orthop. .


Recent studies have shown high early failure rates with Cup Cage constructs in complex revision surgery for Paprosky 3B acetabular defects. As a result, the use of 3D printed custom-made acetabular components has become more common. In this case series, we present two cases that demonstrate the latest advancement in 3D printed implants for severe acetabular bone loss. The follow up was 3 and 7 years. Neither patient has undergone revision surgery of the acetabular component to date. One patient sustained a femoral peri-prosthetic fracture requiring plate fixation. This case study demonstrates that 3D printed implants have excellent intraoperative and immediate postoperative outcomes in revision surgery for severe acetabular bone defects.

Keywords: Acetabular defects; Acetabular implants; Acetabular replacement; Revision surgery.

Conflict of interest statement

Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest.

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